Comparative analysis of exon/intron organization of genes and their resulting protein structures is important for understanding evolutionary relationships between species, rules of protein organization, and protein functionality. We present SEDB, the Structural Exon Database, with a web interface, an application which allows users to retrieve the exon/intron organization of genes and map the location of the exon boundaries and intron phase onto a multiple structural alignment. SEDB is linked with Friend, an integrated analytical multiple sequence/structure viewer, which allows simultaneous visualization of exon boundaries on structure and sequence alignments. With SEDB researchers can study the correlations of gene structure with the properties of the encoded three-dimensional protein structures across eukaryotic organisms.
 
An Integrated Analytical Front-End Application for Bioinformatics, Friend must be installed on your machine first to use the datasets, the installation is quick and easy, and once the application is installed just open wherever you see buttons. All services of SEDB are listed to the left.

In citing SEDB please refer to:

Leslin CM, Abyzov A, Ilyin VA. 2004. Structural exon database, SEDB, mapping exon boundaries on multiple protein structures. Bioinformatics. 2004 Jul 22;20(11):1801-3.
PubMed

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email to Chesley Leslin:
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