Comparative analysis
of exon/intron organization of genes and their resulting protein structures
is important for understanding evolutionary relationships between species,
rules of protein organization, and protein functionality. We present SEDB, the
Structural Exon Database, with a web interface, an application which allows
users to retrieve the exon/intron organization of genes and map the location
of the exon boundaries and intron phase onto a multiple structural
alignment. SEDB is linked with
Friend, an integrated analytical multiple sequence/structure viewer,
which allows simultaneous visualization of exon boundaries on structure and
sequence alignments. With SEDB researchers can study the correlations of
gene structure with the properties of the encoded three-dimensional protein
structures across eukaryotic organisms.
An Integrated Analytical Front-End Application for Bioinformatics,
Friend must be installed on your machine first to use the datasets, the installation
is quick and easy, and once the application is installed just open wherever you see
buttons. All services of SEDB are
listed to the left.
In citing SEDB please refer to:
Leslin CM, Abyzov A, Ilyin VA. 2004. Structural exon database, SEDB, mapping exon boundaries on multiple protein structures. Bioinformatics. 2004 Jul 22;20(11):1801-3.
PubMed
In citing SEDB please refer to:
Leslin CM, Abyzov A, Ilyin VA. 2004. Structural exon database, SEDB, mapping exon boundaries on multiple protein structures. Bioinformatics. 2004 Jul 22;20(11):1801-3.
PubMed
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email to Valentin Ilyin:  email to Chesley Leslin:  |
http://mozart.bio.neu.edu/ 134 Mugar, Biology Northeastern University 360 Huntigton Ave, Boston, MA 02115 tel. (617) 373-7049 • fax (617)-373-3724 |