StSNP Structure SNP

Single nucleotide polymorphisms (SNPs) are DNA sequence variations which occur when a single nucleotide in the genome sequence is altered. Nonsynonymous single nucleotide polymorphisms (nsSNPs) bring in amino acid polymorphism into their encoded proteins. nsSNPs have relationships in disease processes. Effecting protein function, reducing protein solubility are among the several effects of nsSNPs.

Structure SNP (StSNP) webserver which compare structural nsSNP distributions in many proteins or protein complexes. StSNP enables to researchers to map nsSNPs onto protein structures by comparative modeling of structure with nsSNPs by MODELLER (http://salilab.org) and visualize their structural locations by using the multiple structure-sequence viewer Friend. Pathway information is provided from KEGG database. StSNP includes human nsSNPs.

Recent presentation about StSNP Recomb2005
In citing StSNP please refer to: Uzun A, Leslin CM, Abyzov A, Ilyin V.
Structure SNP (StSNP): a web server for mapping and modeling nsSNPs on protein structures with linkage to metabolic pathways.
Nucleic Acids Res. 2007 Jul 1;35:W384-92.

Current statistics for StSNP v1.1
nsSNPs	107,028	NCBI's dbSNP, build 130 April 30, 2009
Protein sequences	31,834	NCBI's Protein June 5, 2009
Genes	12,741	NCBI's Entrez Gene Oct 07, 2005
Protein structures	30,517	PDB June 5, 2009

SEARCH StSNP	Help Information
by a protein sequence identification number. Example: NP_000843
by a PDB code. Example: 1att
by a keyword or full name of the protein. Example: glutathione transferase

Search nsSNPs within metabolic pathways

Search gene for nsSNPs and protein

Example: ACADL

Top 500 proteins that have the most number of nsSNPs

Get proteins with following substutions

in chromosome Residue 1 Residue 2

(residue 1 refers to reference SNP and residue 2 refers to nsSNP)

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