Single nucleotide polymorphisms (SNPs) are DNA sequence variations which occur when a single nucleotide in the genome sequence is altered. Nonsynonymous single nucleotide polymorphisms (nsSNPs) bring in amino acid polymorphism into their encoded proteins. nsSNPs have relationships in disease processes. Effecting protein function, reducing protein solubility are among the several effects of nsSNPs.

Structure SNP (StSNP) webserver which compare structural nsSNP distributions in many proteins or protein complexes. StSNP enables to researchers to map nsSNPs onto protein structures by comparative modeling of structure with nsSNPs by MODELLER (http://salilab.org) and visualize their structural locations by using the multiple structure-sequence viewer Friend. Pathway information is provided from KEGG database. StSNP includes human nsSNPs.

Recent presentation about StSNP Recomb2005

Current statistics for StSNP v1.0
nsSNPs 33,692

NCBI's dbSNP, build 125
Oct 07, 2005
Protein sequences 14,858 NCBI's Protein
Oct 07, 2005
Genes 12,741 NCBI's Entrez Gene
Oct 07, 2005
Protein structures 25,617 PDB
Jan 16, 2007

 
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Help Information

by a protein sequence identification number.

Example: NP_000843

by a PDB code.

Example: 1att
by a keyword or full name of the protein.

Example: glutathione transferase

Search nsSNPs by rs_number

Example: 11553892

Search nsSNPs within metabolic pathways
Search gene for nsSNPs and protein

Example: ACADL
Top 500 proteins that have the most number of nsSNPs

Get proteins length between 0 - aa and % similarity with available structures more than

Get proteins with following substutions

in chromosome Residue 1 Residue 2

(residue 1 refers to reference SNP and residue 2 refers to nsSNP)

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